Hypolipidemic, Hypoglycemic and Antiproliferate Properties of Chia Seed Oil and its blends with Selected Vegetable Oils-An in- vitro study

Numerous studies conclude that inflammatory pathways predommint the pathophysiology of major metabolic syndromes like of diabetes and cardiovascular diseases (CVD). In particular, pancreatic lipase is increased during diabetes and CVD pathology. There is a gradual hepatotoxicity associated with the modern allopathic drugs though efficiently maintain the blood glucose levels but on a long run injure the vital tissues like kidney and liver. Rich content of n-3 fatty acids like α-linolenic acid (ALA) render chia (Salvia hispanica L.), as a potential candidate for metabolic disorders. In our study, chia seed oil and its blends with the selected vegetable oils such as olive oil, palmolein oil and soybean oil reduced the glucose uptake in porcine diaphragm and also reduced gluconeogenesis in hepatocytes. Further, chia seed oil reduced the lipase activity in vitro. Interestingly, our data indicated a strong cytotoxic effects of chia seed oil and combinations against Human lymphoblastic leukemic (CEM ) cancer cells. Together, our results suggest a potential therapeutic role for chia seed oil and its combinations with other vegetable oils which leads to promoting it as a functional food.